rapidpbpk

All parameters are user defined.

Density (g/cm³)

Molecular Weight (g/mol)

logKow (Octanol: Water Coefficient)

Water Solubility (mg/L)

Vapor Pressure at 25 ° C (Pa)

Fraction Reabsorbed in Kidney

The sex and age must be entered by the user. All other parameters will be estimated by PLETHEM. However the user may supercede any of the parameters predicted by PLETHEM.

Organism

Sex

Age (years)

Body Weight (kg)

Cardiac Output (L/h)

Fractional Blood Compartment Volume

Total Fractional Perfused Tissue

Qalv (L/h)

Urinary Flow Rate (mL/kg/day)

Glomerular Filtration (L/h)

Total Tissue Volume as a Percentage of Perfused Tissue:

Total Blood Flow as a Pecentage of Cardiac Output:

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Bone Tissue to Total Bone Volume Ratio

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Brain Tissue to Total Brain Volume Ratio

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Fat Tissue to Total Fat Volume Ratio

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

GI Tissue to Total GI Volume Ratio

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Heart Tissue to Total Heart Volume Ratio

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Kidney Tissue to Total Kidney Volume Ratio

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Liver Tissue to Total Liver Volume Ratio

Volume (Fraction of Body Weight)

Lung Tissue to Total Lung Volume Ratio

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Muscle Tissue to Total Muscle Volume Ratio

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Rapidly Perfused Tissue to Total Rapidly Perfused Volume Ratio

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Skin Tissue to Total Skin Volume Ratio

Skin Surface Area (cm²)

Skin Thickness (cm)

Volume (Fraction of Body Weight)

Blood Flow (Fraction of Cardiac Output)

Slowly Perfused Tissue to Total Slowly Perfused Volume Ratio

Rate of Absorption in Gut Lumen (/h)

Rate of Transfer from the Vehicle to the Gut Lumen (/h)

Blood Air Partition Coefficient

Stratum Corneum Permeability Coefficient (cm/h)

The fat partition coefficient will be calculated from the selected QSAR model.

Fat Partition Coefficient

Fat Permeability Coefficient

The skin partition coefficient will be calculated from the selected QSAR model.

Skin Partition Coefficient

The muscle partition coefficient will be calculated from the selected QSAR model.

Muscle Partition Coefficient

Muscle Permeability Coefficient

The bone partition coefficient will be calculated from the selected QSAR model.

Bone Partition Coefficient

Bone Permeability Coefficient

The brain partition coefficient will be calculated from the selected QSAR model.

Brain Partition Coefficient

Brain Permeability Coefficient

The heart partition coefficient will be calculated from the selected QSAR model.

Heart Partition Coefficient

Heart Permeability Coefficient

The GI partition coefficient will be calculated from the selected QSAR model.

GI Partition Coefficient

GI Permeability Coefficient

The liver partition coefficient will be calculated from the selected QSAR model.

Liver Partition Coefficient

Liver Permeability Coefficient

The kidney partition coefficient will be calculated from the selected QSAR model.

Kidney Partition Coefficient

Kidney Permeability Coefficient

The RPF tissue partition coefficient will be calculated from the selected QSAR model.

RPF Tissue Partition Coefficient

RPF Tissue Permeability Coefficient

The SPF tissue partition coefficient will be calculated from the selected QSAR model.

SPF Tissue Partition Coefficient

SPF Tissue Permeability Coefficient

Michaelis-Menten Constant for Metabolism (µM) [k_m]

Maximum Metabolism Rate (µmol/h/kg BW^0.75) [V_max]

First Order Metabolism in Liver (L/h) [Clearance]

Rate of Metabolism in the Gut lumen(/h)

The rate of fecal excretion is defined by the user.

Rate of Fecal Excretion (/h)

Simulation Start Time

Simulation Duration

Run Monte Carlo

Number of Monte Carlo Runs

Plots

Concentration Plots

Plot

Amount Plots

Plot

Mass Balance Plots

Plot