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Model Setup
Model Output
PLETHEM
ecotoxPBPK version 2.0
Exposure
Chemical
Physiological
Uncertainty and Variability
Simulations
Add New Exposure
Overwrite Exposure
Exposure Description
Exposure Parameters
Concentration in Water (mg/L)
Add New Chemical
Overwrite Existing Chemical
Chemical Description
Chemical Parameters
Molecular Weight (g/mol)
Metabolism
Intrinsic Clearance
Maximum Metabolism Rate (mg/h)
Michaelis-Menten Constant for Metabolism (mg/L)
Intrinsic Clearance (L/h)
Use Intrinsic Clearance
Add New Physiological Set
Overwrite Physiological Set
Physiological Description
Physiological
Organism
Rainbow Trout
Channel Catfish
Load Organism Parameters
Body Weight (kg)
Cardiac Output (L/h)
Effective respiratory rate (L/h)
Blood-Water Partition Coefficient
*Warning: Loading a new organism will overwrite current parameters.
Fat
Volume (L)
Blood Flow (Fraction of Cardiac Output)
Partition Coefficient
Liver
Volume (L)
Blood Flow (Fraction of Cardiac Output)
Partition Coefficient
Kidney
Volume (L)
Blood Flow (Fraction of Cardiac Output)
Partition Coefficient
Rapidly Perfused Tissue
Volume (L)
Blood Flow (Fraction of Cardiac Output)
Partition Coefficient
Slowly/Poorly Perfused Tissue
Volume (L)
Blood Flow (Fraction of Cardiac Output)
Partition Coefficient
Exposure Variability
Add New Variability Set
Edit Variability Set
Exposure Variability Description
Physiological Variability
Add New Variability Set
Edit Variability Set
Physiological Variability Description
Create Simulation
Run Simulation
Select a Simulation
Simulation Description
Simulation Start (h)
Simulation Duration (h)
Chemical Name
Exposure Name
Plots
Parameters
Concentration Plots
Select Compartment
Total Fat
Total Liver
Total Kidney
Total Rapidly Perfused
Total Slowly Perfused
Total Metabolite
Mass Balance Plots
Exposure Parameters
Chemical Specific Parameters
Physiological Parameters
